고삼추출물의 항우식효과와 세포독성
Anticaries effect and cytotoxicity of extract of Soph ora flavescens Ait.
이현옥,
소속 상세정보
이현옥 ( ) - 원광보건대학 치위생과
KMID : 0355420010250040333
Abstract
The purpose of this study is to investigate anticaries activities of Sophora flavescens Ait, extracts for the prevention of dental caries caused by Streptococcus mutans. The fraction 5-4-3 of the ethyl acetate soluble extract of Sophora flavescens Ait. showed strong growth inhibition activity against Streptococcus mutans(MIC, 3.13 ug/ml ). The glucosyltransferase activity inhibited the formation of glucan by the fraction 5-4-3 and showed 77% of the antiproliferative effect at 100 ug/ml. The activity was statistically significant(p (0.05). These results suggest that the fraction 5-4-3 of the ethyl acetate soluble extract of Sophora flavescens Alt. may be a effective material on the prevention of dental caries.
키워드
고삼;추출물;항세균효과;최소억제농도;glucosyltransferase;세포독성
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